Pulmonary Contusion Primes Systemic Innate Immunity Responses

Ambient ozone primes pulmonary innate immunity in mice.

Exposure to ozone in air pollution in urban environments is associated with increases in pulmonary-related hospitalizations and mortality. Because ozone also alters clearance of pulmonary bacterial pathogens, we hypothesized that inhalation of ozone modifies innate immunity in the lung. To address our hypothesis, we exposed C57BL/6J mice to either free air or ozone, and then subsequently challe...

Ozone and pulmonary innate immunity.

Ambient ozone (O(3)) is a commonly encountered environmental air pollutant with considerable impact on public health. Many other inhaled environmental toxicants can substantially affect pulmonary immune responses. Therefore, it is of considerable interest to better understand the complex interaction between environmental airway irritants and immunologically based human disease. The innate immun...

Innate Immunity Sublethal Hyperoxia Impairs Pulmonary

Masquerading pneumonia--pulmonary contusion.

Pneumonia is diagnosed and treated with symptoms of fever, cough, expectoration and chest X ray showing evidence of consolidation. When a pattern of opacification does not fit into segmental or lobar pattern, reevaluation is essential. We report a case of 18 yr old boy with symptoms of respiratory infection, and X ray diagnosis suggestive of infective consolidation which turned out to be a case...

Innate immunity in systemic lupus erythematosus: sensing endogenous nucleic acids.

Historically, the involvement of complement - an integral part of the innate immune response- in the pathogenesis of lupus was recognized early. Emphasis shifted quickly however to the specific immunity with scientists concentrating on the adaptive immune response (autoantigens, autoreactive T cells and autoantibodies). Similarly, the detection of interferon alpha (IFNα), another key mediator o...